, 2006; Sawaya and Kraut, 1997; Figure 1—determine health supplement one), we predicted the mutational landscape of DHFR to get constrained via the prerequisite to adopt these unique conformations. In addition, prior do the job had proposed DHFR is impacted by mobile constraints like protein quality Regulate (Bershtein et al., 2013) as well as Construct-up of the harmful metabolic intermediate (Schober et al., 2019). We as a result anticipated deep mutational scanning to expose a remarkably constrained mutational landscape for DHFR that will contrast with the mutational tolerance observed in other methods.
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